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analogies essay man Pope wrote his Essay on Man in Character rhyming verse. Certainly today, we think anybody that writes poetry is one who is a bit odd, to say the Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, least. Personal Letter. Back in the eighteenth century, it was not so strange. Pope stated that he had two reasons for writing his essay in such a manner. Digital Storyboard Templates. First, he thought that principles, maxims, or precepts so written, both strike the reader more strongly at first, and are more easily retained by him afterwards. The second reason that Pope gave is Personal Character, that he thought that he could express himself more shortly this way than in prose itself.

I here make comments about the expressions and thoughts of Pope in his essay. I have quoted at length from his essay. Digital Storyboard Template. Templates 13. Certainly there is much I have left out, because, likely, certain verses referred to events, persons and things of the early eighteenth century which, quite frankly, I am unfamiliar with. Letter. Spattered throughout Pope's work are references to God and His great domain. Cna Appreciation On Pinterest | Nursing. Such references in the writings out of the eighteenth century are not strange. The livelihood of writers, by and large -- as was with the Personal Character Letter, case of all artists back then -- depended almost entirely on the generosity of church and state, so it was necessary in those days that writers give due regard to religious authority.

Believing that if Pope were looking over my shoulder he would have no objection, I have left out religious epaulets. Within the first few lines, we see Pope wondering about the fruitlessness of life. We have no choice: we come to it, look out and then die. What we see as we look out on Post Thank Thank You Letter Post Interview, the scene of Personal, man is a mighty maze! But Pope does not think this complex of existence is without a plan. Man might sort through the Post Interview You Letter. You Letter Post Interview, maze because he has a marvelous mental faculty, that of reason; man can determine the nature of the world in which he lives; he can see that all things have bearings, ties and strong connections and nice dependencies. He, who thro' vast immensity can pierce, See worlds on worlds compose one universe, Observe how system into system runs, What other planets circle other suns, Look'd thro'? or can a part contain the whole? Is the great chain that draws all to agree, - And, drawn, supports - upheld by God or thee? In his next stanza, Pope makes reference to presumptuous man! Why should one be disturbed because he cannot immediately figure out all of the mysteries with which he is presented?

It cannot be expected that one part of existence (man) should understand all the other parts, he then continues: As of thy mother Earth, why oaks are made. Character. Taller or stronger than the weeds they shade. And all that rises, rise in due degree; Then, in the sale of Thank You Letter. You Letter Post Interview, reas'ning life, 'tis plain. There must be, somewhere, such a rank as Man. When the Personal Letter, dull ox, why now he breaks the clod, Is now a victim, and now Egypt's god, - Then say not Man's imperfect, Heav'n in fault, - Say rather Man's as perfect as he ought: His knowledge measur'd to his state and Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 place, His time a moment, and a point his space. Pope continues with this theme into Personal Character Letter his third stanza, in saying Heav'n from all creatures hides the book of Story Chart Example - Edgrafik, fate, and continues: The lamb thy riot dooms to bleed to-day, Had he thy reason, would he skip and play? Pleas'd to the last he crops the flow'ry food, And licks the hand just rais'd to shed his blood. Who sees with equal eye, as God of Personal Letter, all, A hero perish, or a sparrow fall, Atoms or systems into ruin hurl'd, And now a bubble burst, and now a world.

Then giving way to his religious bent, makes reference to the great teacher Death and continues with his most famous lines: Hope springs eternal in Template. 13 the human breast; Man never is, but always to be blest: The soul uneasy and confin'd from home, Rest and expatiates in a life to come. Next, Pope deals with native people of the uncivilized territories of the world, and how they do not get hung up on such large questions as are expressed in Pope's essay: Lo, the poor Indian! whose untutor'd mind. Sees God in clouds, or hears him in the wind; His soul proud Science never taught to Letter stray. Far as the Cna Appreciation On Pinterest Assistant, solar walk or milky way; Yet simple Nature to Character Letter his hope has giv'n, Behind the cloud-topp'd hill, a humbler heav'n; Some safer world in depth of Hpe Competitive Analysis 02282017, woods embrac'd, Some happier island in the wat'ry waste, Where slaves once more their native land behold, No fiends torment, no Christians thirst for Letter, gold!

To be, contents his natural desire; He asks no angel's wing, no seraph's fire: But things, admitted to that equal sky, His faithful dog shall bear him company. Hpe Competitive Analysis 02282017. Next, we see Pope start to develop the theme that runs throughout his essay; man is part of a larger setting, a part of nature. Man depends on nature for Personal Character, his very substance, and yet, treats her roughly. Cna Appreciation | Nursing Assistant. Destroy all creatures for thy sport or gust, Yet cry, if Man's unhappy, God's unjust; Ask for what end the Personal Character Letter, heav'nly bodies shine, Earth for whose use, Pride answers, 'Tis for mine! For me kind Nature wakes her genial pow'r, Suckles each herb and spreads out ev'ry flow'r; Pope asserts that man is ruled from within, by his reason and by his passion. Better for us, perhaps, it might appear, Were there are harmony, all virtue here; That never air or ocean felt the 20 Best Images On Pinterest, wind; That never passion discompos'd the mind. Personal Character Letter. But all subsists by elemental strife; And passions are the elements of life. The gen'ral Order since the whole began. Is kept in Nature, and is kept in Man.

Passion may be equated to instinct; and Digital Printable Storyboard 13 instinct is the sole guide of Character Letter, animals. Instinct is Templates For College, all that animals need as evolution has fitted each animal to his home environment, unlike man who is in want of the strength of bulls, the fur of bears. Here with degrees of Personal Character, swiftness, there of force: All in exact proportion to the state; Nothing to add, and nothing to Story Example abate. Each beast, each insect, happy in its own: Is Heav'n unkind to Man, and Man alone? Shall he alone, whom rational we call, Be pleas'd with nothing, if not bless'd with all? Again, Pope emphasizes how nature all good and wise. and Letter what it gives, and what denies has perfected itself and many of its creations: The spider's tough how exquisitely fine!

Feels at each thread, and lives along the line: In the nice bee, what sense so subtly true. From pois'nous herbs extracts the Resume, healing dew? In nature, we find life in a complete variety, - vast chain of being everything beast, bird, fish, insect. Or in the full creation leave a void, Where, one step broken, the great scale's destroy'd: From Nature's chain whatever link you strike, Tenth or ten thousandth, breaks the Personal, chain alike. The point, I think, is that there is Plot Chart Example - Edgrafik, a fearful balance of nature in all its variety, and we dare not destroy one aspect of nature for fear of Personal Letter, destroying the whole. All this dread order break - for whom? for Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, thee? Vile worm! - oh madness! pride! impiety!

In the Character Letter, last line of Pope's first epistle, he bangs home the importance of the ruling mind of nature, that while some parts might seem to us to be absurd, it is Post Interview You Letter. Thank You Letter Post Interview, part of the general frame that all of nature, including ourselves, are but parts of one stupendous whole. Character. This whole body of Plot Chart - Edgrafik, nature is through all life and extends throughout all of the universe and operates unspent. Personal Character. Pope concludes his first epistle: Safe in the hand of one disposing Pow'r, Or in the natal, or the Post Thank You Letter Post, mortal hour. All Nature is but Art, unknown to thee; All chance, direction, which thou canst not see. Personal. All discord, harmony not understood, All partial evil, universal good: And, spite of pride, in erring reason's spite, One truth is clear, whatever is, is right. Resume Templates Students. Pope opens his second Epistle much the same as he opened his first.

What is the function of Personal Letter, man, positioned as he is somewhere between a god and a beast. Man, during that brief interlude between birth and death, experiences a chaos of Thank, thought and passion, all confus'd. He finds on earth the Character, Great lord of Templates For College, all things, yet a prey to all. Man's function, Pope concludes, is to make a proper study of mankind ; man is to know himself. What man will come to know is that he is ruled by Letter passion; passion is the Post Thank You Letter. You Letter Post, ruler and reason it's counsellor. Personal. Alas what wonder! Man's superior part.

Uncheck'd may rise and climb from art to art; But when his own great work is but begun, What Reason weaves, by Templates Passion is Letter, undone. It is in the nature of 20 Best Cna Appreciation | Nursing, man to first serve himself; but, on account of Character Letter, reason, to do so with the long range in view. Interview Post. Two Principles in human nature reign; Self-love, to urge, and Reason, to Personal Letter restrain; Self-love still stronger, as its objects nigh; Reason's at distance, and in prospect lie: A person is driven by passion, driven by his desire for pleasure; temptation is strong and passion is thicker than arguments. However, a person soon learns through bitter experience that one cannot let his or her passions run wild.

Attention, habit and experience gains; Each strengthens Reason, and Self-love restrains. Plot Example - Edgrafik. Self-love and Reason to one end aspire, Pain their aversion, Pleasure their desire, Pleasure, or wrong or rightly understood, Our greatest evil, or our greatest good. Passions, tho' selfish, if their means be fair, List under reason, and deserve her care. On life's vast ocean diversely we sail, Reason the Personal, card, but passion is the Hpe Competitive Analysis Report, gale;2. Love, Hope, and Personal Letter Joy, fair Pleasure's smiling train, Hate, Fear, and Grief, the family of Pain, These mix'd with art, and to due bounds confin'd, Make and maintain the Hpe Competitive Report 02282017, balance of the mind: Pope's theme is again repeated: the two driving forces of Personal Letter, man are his reason and Students his passion. Character Letter. However, passion is the king and reason but a weak queen. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119. What can she more than tell us we are fools? Teach us to mourn our nature, not to mend.

A sharp accuser but a helpless friend! Reason (th' Eternal Art, educing good from ill) is not a guide but a guard. Personal. Passion is the | Nursing Assistant, mightier pow'r. Character Letter. Envy, Pope points out as an aside, is something that can be possessed only by Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 those who are learn'd or brave. Personal Character Letter. Ambition: can destroy or save, and makes a patriot as it makes a knave. With Pope's thoughts, it soon becomes clear one should not necessarily consider that envy and ambition are in themselves wrong. They are moving forces in a person and if properly guided, can serve a person well.

As, in You Letter. Thank Post Interview some well-wrought picture, light and Character shade. And oft so mix, the diff'rence is too nice, Where ends the virtue, or begins the Digital Storyboard Printable Storyboard Templates 13, vice. And virtuous and vicious ev'ry man must be, Few in the extreme, but all in the degree; Each person is driven by self-love, but on the same occasion each on the other to depend, a master, or a servant, or a friend, bids each on other for assistance call. Each person seeks his own happiness, seeks his own contentment; each is proud in what he or she has achieved, no matter what another person might think of those achievements. Whate'er the passions, knowledge, fame, or pelf, Not one will change is Character Letter, neighbour with himself. The learn'd is happy nature to explore, The fool is Story Chart, happy that he knows no more; The rich is happy in the plenty given, The poor contents him with the Character, care of Heaven, See the blind beggar dance, the cripple sing.

The sot a hero, lunatic a king; The starving chemist in his golden views. Supremely bless'd, the 20 Best, poet in his Muse. Character Letter. None of Thank Interview, us should be critical of another person's choice in Character life, who is to know it is right. Behold the Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, child, by Personal nature's kindly law, Pleased with a rattle, tickled with a straw: Some livelier plaything give his youth delight, A little louder, but as empty quite: Scarfs, garters, gold, amuse his riper stage, And beads and prayer-books are the toys of age: Pleased with this bauble still, as that before, Till tired he sleeps, and life's poor play is o'er. Pope returns, in Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 his third Epistle, to his ever present theme, all is natural in nature and man is a part of nature. He first observes how plastic nature is, how everything is dependant on one and Character Letter the other, is attracted to one and the other, down even to single atoms. Everything it's neighbour to embrace. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119. (While Pope did not do so, he might just as easily have observed that things in nature repel one another, equally so. All things, in Personal Letter the final analysis, are held in Resume For College Students | the balance, suspended, so it seems, between the Character, two great forces of attraction and Thank Post repulsion.) All forms that perish other forms supply, (By turns we catch the vital breath, and die) Like bubbles on the sea a matter borne, They rise, they break, and to that sea return.

Nothing is foreign; parts relate to whole: Then, Pope picks up once again his theme of the ruling principles, reason and passion. Here in his third Epistle, he refers to Personal Letter instinct as the unerring guide that reason often fails us, though sometimes serves when press'd. But honest instinct comes a volunteer, Sure never to o'ershoot, but just to hit, While still to wide or short is human wit; Sure by quick nature happiness to gain, Which heavier reason labour at in vain. Instinct can be seen at Report work throughout nature, for example, Who make the spider parallels design . without rule or line? Not just the spider does things by instinct, man does. The obvious example is his artistic work, but our instincts serve us on a much broader range. Think! And you will wonder about many of the daily things that are done, automatically it seems. What, exactly, is it that prompts us to do things.

Who calls the Personal Character, council, states the certain day, Who forms the phalanx, and who points the Hpe Competitive Report, way? Pope then comes to a rather critical passage in Personal Character Letter his essay, when he deals with family units in the animal kingdom versus human beings. The fact of the matter is, family units do not count for Plot Example - Edgrafik, much in the animal kingdom, at any rate, not for Personal Character, long. However, family connections for human beings extend over a long period, indeed, over a lifetime. I would observe that it is an evolutionary development, needed because of the Digital Template., long time required before a child passes into adulthood.

These family feelings are important for the development and Personal cohesion of the family, but not necessarily good when extended to the larger group, society as a whole (this is a theme that I have developed elsewhere (EconEcon.doc) and which someday I hope to put up on the 'net.). Thus beast and 20 Best Cna Appreciation Images bird their common charge attend, The mothers nurse it, and Character Letter the sires defend: The young dismiss'd to wander earth or air, There stops the instinct, and there ends the care; The link dissolves, each seeks a fresh embrace, Another love succeeds, another race. A longer care man's helpless kind demands; That longer care contracts more lasting bands: Reflection, reason, still the ties improve, At one extend the interest, and the love; With choice we fix, with sympathy we burn; Each virtue in each passion takes its turn; And still new needs, new helps, new habits rise. That graft benevolence on charities. 20 Best. Still as one brood, and as another rose, These natural love maintain'd, habitual those: The last, scarce ripen'd into perfect man, Saw helpless from him whom their life began: Memory and forecast just returns engage; That pointed back to youth, this on Character, to age; While pleasure, gratitude, and Report hope, combined, Still spread the interest, and preserved the Personal Letter, kind. Pope then, continuing with his third Epistle, returns to his principle and Interview Thank Thank You Letter Post Interview the power of nature. Nature is a driving gale, a fact which can be observed in the voice of nature and Letter which we can learn from the birds and the beasts. It was the power of nature that built the ant's republic and the realm of bees. Pope observes anarchy without confusion.

Their separate cells and properties maintain. Mark what unvaried laws preserve each state;- Laws wise as nature, and as fix'd as fate. In vain thy reason finer webs shall draw; Entangle justice in her net of law; And right, too rigid, harden into Resume Templates wrong, Still for Personal Character Letter, the strong too weak, the Story Example - Edgrafik, weak too strong. Yet go! and thus o'er all the creatures sway; Thus let the Personal, wiser make the rest obey; And for those arts mere instinct could afford, Be crown'd as monarchs, or as gods adored.

It is the same voice of nature by Post Thank Thank You Letter Post Interview which men evolved and cities were built, societies were made. That while men in the gradual and slow build-up ravished one another with war, it was commerce that brought about civilization. Men came to new countries with war-like intentions, but soon became friends when they realized there was much more profit in trade. When love was liberty, and Character nature law: Thus states were form'd; the name of king unknown, Till common interest placed the sway in one. 'Twas Virtue only, or in arts or arms, So, it was trade that built civilizations, and Pope observes, that it was tradition that preserves them. Convey'd unbroken faith from sire to son; The worker from the work distinct was known, Then, continuing in this historical vein, Pope deals with the development of government and of laws. So drives self-love, through just and through unjust. To one man's power, ambition, lucre, lust: The same self-love, in 20 Best On Pinterest | Nursing Assistant all, becomes the cause. Of what restrains him, government and laws: For, what one likes if others like as well, What serves one will, when many wills rebel?

How shall we keep, what, sleeping or awake, A weaker may surprise, a stronger take? His safety must his liberty restrain: All join to guard what each desires to gain. Personal Character Letter. Forced into virtue thus by self-defence, Ev'n kings learn'd justice and Story Plot Chart - Edgrafik benevolence: Self-love forsook the path it first pursued, And found the private in the public good. 'Twas then, the studious head or generous mind, Follower of God or friend of human-kind, Poet or patriot, rose but to restore. The faith and Personal Character Letter moral Nature gave before; Relumed her ancient light, not kindled new; If not God's image, yet his shadow drew; Taught power's due use to people and to kings; Taught not to 20 Best Images Assistant slack nor strain its tender strings; The less or greater set so justly true, That touching one must strike the other too;

Till jarring int'rests of themselves create. Th' according music of a well-mix'd state. Such is the world's great harmony, that springs. From order, union, full consent of things: Where small and great, where weak and mighty made. To serve, not suffer, strengthen, not invade; More pow'rful each as needful to the rest, And in Character proportion as it blesses, blest; Draw to one point, and to one centre bring.

Beast, man, or angel, servant, lord, or king. Pope makes a side observation that while government is necessary, its form is of less importance, what is important, is a good administration: For forms of government let fools contest; Whate'er is best administer'd is best: Pope then concludes in his third Epistle, emphasizing that regard for Example - Edgrafik, oneself and his family has to be different than regard for the whole of society, that nature link'd the gen'ral frame and bade self-love and social be the same. In his last Epistle on the Essay of Man, Pope deals with the subject of happiness. Character. It may be any one of Cna Appreciation On Pinterest, a number of things, it depends on the person: good, pleasure, ease, content! whatever thy name. That happiness as a plant of celestial seed will grow, and if it doesn't, one should not blame the soil, but rather the Personal Character, way one tends the Story Chart Example, soil. Though man may well seek happiness in many quarters, it will only be found in nature.

Man should avoid extremes. Character Letter. He should not go about in life trusting everything, but on Interview Thank Interview, the same occasion neither should he be a total skeptic. Take Nature's path, and made Opinion's leave; All states can reach it and all heads conceive; Obvious her goods, in Personal Letter no extreme they dwell; There needs but thinking right, and meaning well; And mourn our various portions as we please, Equal is common sense, and common ease. To Pope, pleasure does not last, it sicken, and all glories sink.

To each person comes his or her share and Resume Templates who would more obtain, Shall find the pleasure pays not half the Character, pain. To be rich, to be wise: these are both laudable goals and a person looking about will always be able to find others who have riches and wisdom in varying degrees, but it cannot be concluded to any degree that they are happy. Happiness comes when one has health, peace, and Chart Example - Edgrafik competence. It is not clear to me from Pope's lines how one might secure peace and competence; health, he says, consists with temperance alone. It is in the nature of Personal, man to attempt to change things; he is never happy with things as he finds them; never happy with his fellow man; never happy with the world about Hpe Competitive Analysis Report, him. We forever strive to make things perfect, a state that can hardly be define in human terms. Those that reflect on man's condition will soon have Utopian dreams. But still this world, so fitted for the knave, Contents us not.

A better shall we have? A kingdom of the Character Letter, just then let it be: But first consider how those just agree. The good must merit God's peculiar care; But who but God can tell us who they are? It all too often appears to us that virtue starves, while vice is fed. Printable Storyboard 13. One might wish for man to be a God and for earth to be a heaven, both God and heaven coming from the imaginations of man. Character. But, Pope concludes: 'Whatever is, is right.' -- This world, 'tis true. Of fame, Pope says, it is but a fancied life in others' breath . 20 Best Images Assistant. All that we feel of it begins and Letter ends in the small circle of our foes and friends . It will get you nothing but a crowd of stupid starers and of loud huzzas. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119. Of wisdom, Pope attempts a definition and Personal points out how often the Digital Storyboard 13, wise are bound to trudge alone with neither help nor understanding from his fellow man. In parts superior what advantage lies!

Tell, for you can, what is Character Letter, it to be wise? 'Tis but to know how little can be known ; To see all others' faults, and feel our own: Condem'd in business or in arts to drudge, Without a second, or without a judge: Truths would you teach, or save a sinking land? All fear, none aid you, and Resume For College Students few understand. And so we arrive at the last of Pope's lines. Show'd erring Pride, WHATEVER IS, IS RIGHT; That Reason, Passion, answer one great aim; That true Self-love and Personal Social are the same . 1 The Poetical Works of Alexander Pope which includes Dr. Johnson's 65 page biography on Plot Example, Pope, Essay on Man (31 pp.); Essay on Criticism (17 pp.), Rape of the Character, Lock (19 pp.), The Dunciad (31 pp.).

My vintage copy has within it two frontispiece Steel Engravings (Philadelphia: Hazard, 1857). 2 Here, again, we see Pope refer to | the analogy of the sailing ship on the sea finding its way only with compass (card) for direction and the wind in the sails to drive the vessel along.

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The virus belongs to the family Parvoviridae, which includes two genera of vertebrate viruses: genus parvovirus (autonomously replicating parvoviruses) and genus dependovirus (parvoviruses that require a helper virus, such as adenovirus or herpes virus, for replication); and one genus of Personal Character invertebrate viruses, the genus densovirus (15). B19 is in the genus parvovirus, which includes a number of animal parvoviruses such as the canine parvovirus and feline panleukopenia virus. The parvoviruses tend to be species-specific; only the Students, adeno-associated parvoviruses (members of the dependovirus genus) and B19 are known to infect humans. The adeno-associated parvoviruses have not been associated with disease in Letter, humans. Fecal parvoviruses and the RA1 virus have been reported but not confirmed to Templates For College be human pathogens (16,17).

B19 is Personal a heat-stable virus and can survive at 60 C (140 F) for up to 12 hours. Story Chart - Edgrafik! CLINICAL FEATURES OF B19 INFECTION Erythema Infectiosum (Fifth Disease) The most commonly recognized illness associated with B19 infection is EI. EI is a mild childhood illness characterized by a facial rash (slapped cheek appearance), and a reticulated or lacelike rash on the trunk and extremities (18). Reappearance of the rash may occur for several weeks following nonspecific stimuli such as change in temperature, sunlight, and emotional stress. Typically, the patient is otherwise well at rash onset but often gives a history of mild systemic symptoms 1-4 days before rash onset. In some EI outbreaks, pruritis has been a common clinical feature.

In addition to typical EI, B19 infection has been associated with a variety of other exanthems, including those that are rubella-like, vesicular, and purpuric (18). Asymptomatic Infection. In outbreak investigations, asymptomatic infection has been reported in approximately 20% of Personal Character children and Cna Appreciation On Pinterest | Nursing Assistant, adults (19,20). Personal Letter! Arthropathy. In some outbreaks of Post Interview You Letter. Interview EI, arthralgias and arthritis have been commonly reported (7,8,21). Infection may produce a symmetrical peripheral polyarthropathy. Joints in the hands are most frequently affected, followed by the knees and Personal Character Letter, wrists. Symptoms are usually self-limited but may persist for several months.

Joint symptoms, more common in adults, may occur as the sole manifestation of Story - Edgrafik infection. Transient Aplastic Crisis and Severe Anemia. B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and Personal Character, autoimmune hemolytic anemia) (22,23). It can also cause TAC in other conditions in which increased red cell production is necessary to maintain stable red cell indices, as may occur in anemia due to blood loss. Patients with TAC typically present with pallor, weakness, and lethargy and Post Thank You Letter Post, may report a nonspecific prodromal illness in the preceding 1-7 days. Few patients with TAC report a rash. In the acute phase of the illness, #12;patients usually have a moderate to Character Letter severe anemia with absence f reticulocytes, and bone marrow examination shows a hypoplastic or an aplastic erythroid series with a normal myeloid series. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119! Recovery is indicated by a return of Personal reticulocytes in the peripheral smear approximately 7-10 days after their disappearance. TAC may require transfusion and hospitalization and can be fatal if not treated promptly. B19 Infection in Immunodeficient Patients. A B19-related severe chronic anemia associated with red cell aplasia has been described in You Letter Post, patients on maintenance chemotherapy for acute lymphocytic leukemia, patients with congenital immunodeficiencies, and Personal, patients with human immunodeficiency virus (HIV)-related immunodeficiency (9-14).

It is not yet known how often B19 causes chronic anemia in immunodeficient patients or which patients are most susceptible to this complication of infection. Chronic B19 infection should, however, be included in the differential diagnosis of chronic anemia in Post Interview Thank You Letter. You Letter, the immunodeficient patient. Infection in the Pregnant Woman Intrauterine infection and fetal death. In most of the reported B19 infections occurring during pregnancy, the fetus has not been adversely affected (5,6,24-30). However, in some cases B19 infection has been associated with fetal death. The risk of fetal death attributable to Personal Letter parvovirus infection following documented maternal infection (B19 IgM-antibody-positive) is not known, but preliminary results of one study from the United Kingdom suggest that it is less than 10% (30; SM Hall, unpublished data). In that study, 174 pregnant women with IgM antibody to B19 were followed prospectively to delivery. Story Plot! Fetal loss occurred in 30 (17.2%): 21 (19.1%) of 110 women infected during the first 12 weeks of pregnancy, seven (15.2%) of 46 women infected during weeks 13-20, one (6.3%) of 16 women infected after 20 weeks, and one of two women with unknown time of infection. Fetal death most commonly occurred from the Personal Character, 10th through the 20th weeks of pregnancy. Not all fetal deaths directly resulted from Story Example, B19 infection. Since this study did not include a control group, the number of deaths attributable to B19 infection cannot be calculated directly.

In other studies, rates of recognized pregnancies ending in spontaneous abortions from all causes by Personal, 28 weeks' gestation range from Templates For College Students |, 10% to 25% (31). In the British study, the number of fetal deaths linked to B19 infection can be estimated by Personal, determining whether fetal tissues contain B19 DNA. Tissues from 14 fetuses were tested for B19 DNA: six were positive, two were equivocal, and six were negative. The cause of death is likely to Storyboard Template. have been B19 infection for the DNA-positive fetuses; thus, at Personal, least six (3.4%) of 174 infected women were likely to have had a B19-associated fetal loss. When the Digital Storyboard Template. Printable Storyboard, results of the 14 tested were extrapolated to all 30 fetal deaths, an estimated 17 fetuses would be B19 DNA-positive or equivocal, suggesting that less than or equal to17 (less than or equal to9.8%) of the Character, 174 B19-infected women might have had a B19-associated fetal loss. Antibody studies of Template. 13 liveborn infants and hybridization studies of fetal tissues indicate that less than one third of maternal infections are associated with fetal infection in this study.

Results from an ongoing study in the United States also suggest that B19- attributable fetal deaths are infrequent (CDC, unpublished data). Personal! In this study, 95 pregnant women with IgM antibody to B19 are being followed prospectively. Fetal loss has so far occurred in two (4.1%) of 49 women followed to term. It is Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 not known whether the two fetal deaths were caused by B19 infection. One fetus was hydropic; the Character, other was not described. No tissues from either fetus were available for Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 B19 hybridization studies. When the antibody status of the woman is unknown, estimates of the Personal Character Letter, risk of fetal death after exposure must take into account the rate of susceptibility in the population and the risk of infection after the exposure.

For example, by taking these factors into account, the upper limit estimate of the risk of fetal death would be less than 2.5% after exposure to household members with documented infection (less than 0.1 risk of fetal death x 0.5 rate of susceptibility x 0.5 rate of infection x 100; see sections on Epidemiologic Features of B19 Infection: Prevalence and Transmission) and Post Thank You Letter Interview, less than 1.5% after prolonged exposure at schools with widespread EI among students (less than 0.1 risk of fetal death x 0.5 rate of susceptibility x 0.3 rate of infection x 100). The upper limit risk estimate of Personal Character Letter fetal death after other types of exposure (e.g., schools with limited EI among students) is likely to be substantially less. A study of 96 women who had stillbirths, 96 women who had spontaneous abortions, and Students |, controls matched by age, duration of Personal Character Letter pregnancy, and location suggests that B19 is not responsible for a substantial #12;proportion of Post Thank Thank You Letter Post fetal deaths in Personal, the general population (32). In this study, the Hpe Competitive Report, rate of serologically confirmed B19 infection was the same (1%) in cases and Letter, controls. Hpe Competitive Report! In a survey of Personal 50 fetuses with nonimmunologic hydrops fetalis, an uncommonly diagnosed cause of fetal death, four (8%) were positive for B19 DNA (25). Congenital anomalies. Since some of the animal parvoviruses are teratogens (33), the You Letter Interview, possibility that infection may also be associated with congenital anomalies in humans is Letter a concern. However, there is no evidence that the On Pinterest, rate of congenital anomalies following B19 infection exceeds background rates. B19-associated congenital anomalies have not been reported among several hundred liveborn infants of B19-infected mothers. Personal Character! One aborted fetus with eye anomalies and histologic evidence of damage to multiple tissues born to a B19-infected woman has been reported (34).

An anencephalic fetus was reported in a B19-infected woman, but the timing of infection made it unlikely that B19 contributed to the defect (35). ATHOGENESIS. The pathogenesis of the rash in Post Interview Thank Thank Post Interview, EI is unknown, but the rash may be immune- complex-mediated. The other, more serious manifestations of B19 infection are related to the propensity of the virus to infect and lyse erythroid precursor cells and interrupt normal red cell production (36). In a person with normal hematopoiesis, B19 infection produces a self-limited red cell aplasia that is clinically inapparent. Transient leukopenia, lymphocytopenia, and thrombocytopenia have also been reported with B19 infection in the normal host (37,38).

In patients who have increased rates of Personal red cell destruction or loss and who depend on compensatory increases in Template. Printable Storyboard 13, red cell production to maintain stable red cell indices, B19 infection may lead to TAC. Letter! Patients at risk for TAC include those with chronic hemolytic anemias and those with anemias associated with acute or chronic blood loss. Resume Templates For College! In immunodeficient persons, B19 infection may persist, causing chronic red cell aplasia, which results in Letter, chronic anemia; chronic neutropenia has also been described (10). B19 DNA-positive tissues have been reported in Printable Storyboard 13, 20 fetal deaths; in all 17 cases in which pathologic findings were described, the fetuses had nonimmunologic hydrops fetalis (6,25-27,30,35,39-44). The precise pathogenesis of Personal fetal death remains unclear. Severe anemia may precipitate congestive heart failure, generalized edema, and ultimately fetal death.

The fetus may be particularly vulnerable to B19 infection because red cell survival is short, and the red cell volume is rapidly expanding. Severe anemia, B19 viremia, and Story Plot, cytologic changes in erythroid precursor cells have been described in fetuses just before death (26,27,39). Letter! Chronic infection may occur in the fetus (one fetus was viremic for at least 4 weeks) (26). In one case report, infection of myocardial cells was noted, suggesting that direct damage to myocardial tissue may also contribute to the disease process in the fetus (29). EPIDEMIOLOGIC FEATURES OF B19 INFECTION Prevalence. B19 infection occurs worldwide (45,46). Infection with B19 can occur throughout the year, in all age groups, during outbreaks of EI, or as sporadic cases. Post You Letter. Thank Post Interview! B19 infection is most frequently recognized during outbreaks of EI in schools. Character Letter! These outbreaks often begin in late winter or early spring and may continue until school recesses for the summer. Post Thank Thank Post Interview! The level of EI activity in a community varies from year to year; periods of increased activity lasting several years are generally followed by Character Letter, several years of decreased activity (47-50). The reported seroprevalence ranges from 2% to Hpe Competitive Report 02282017 15% in Character, children 1-5 years old, 15% to 60% in Digital Storyboard Templates 13, children 5-19 years old, and 30% to 60% in adults (18,40,51,52).

Incubation Period. Studies of secondary illness in households suggest that the incubation period for clinical EI and TAC is usually 4-14 days but can be as long as 20 days (18). In volunteer studies, rash illness occurred 17-18 days after inoculation (37,38). Transmission. B19 DNA has been found in respiratory secretions in viremic patients, which suggests that these secretions are involved in transmission (19,20,37). In studies of human volunteers, serum and Personal, respiratory secretions became positive for B19 DNA 5-10 days after intranasal inoculation (during the Hpe Competitive Analysis Report, prodromal illness) (37,38). By the Personal Letter, time of Templates onset of rash or arthralgia, serum specimens had been negative for 1-5 days.

B19 has not been detected in the respiratory secretions and only rarely in Personal Character Letter, the serum of patients after onset of EI (37). In contrast, acute serum specimens are often positive for B19 DNA in patients when they present with TAC; serum specimens are usually negative by 7 days after onset of illness (53). The presence of B19 DNA in serum or respiratory secretions presumably correlates with infectiousness; thus, patients with EI are probably past the Templates For College |, period of greatest infectiousness, while patients with TAC are likely to be #12;infectious during the course of their illness. The presence of IgG antibody correlates with a lower risk of infection. Personal! This decreased risk has been suggested in volunteers who were experimentally inoculated with B19: four of five IgG-negative but only one of four IgG-positive volunteers developed serologic evidence of infection (37). The IgG-positive volunteer who became infected had low levels of Printable Storyboard Templates 13 IgG antibody before challenge and Personal, had a lower titer and shorter duration of viremia than had the four infected volunteers who were IgG-negative. The virus is transmitted effectively after close contact exposures. Plot - Edgrafik! The secondary attack rate for infection among susceptible household contacts of Letter patients with TAC or EI is about 50% (19,20). Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119! In school outbreaks, 10%-60% of students may develop EI. In outbreaks in Personal, which student involvement is widespread, preliminary data suggest 20%-30% of susceptible (IgG-antibody-negative) staff may develop serologic evidence of Digital Storyboard Template. Templates 13 B19 infection during the course of the Personal Character, outbreak (CDC, unpublished data).

In outbreak settings, it is not known whether the primary mode of transmission involves direct person-to-person contact, fomites, large-particle droplets, or small- particle droplets. The virus can also be transmitted parenterally by transfusion of blood or blood products and vertically from mother to fetus (1,54,55). Transmission rarely occurs during transfusion with single-donor blood products but is common during treatment with clotting-factor concentrates even after steam- or dry-heat treatment of the clotting factor concentrate (1,54,55). Tattooing was suspected as the source of B19 transmission in two instances (56). DIAGNOSIS B19 Antibody Assays. The most sensitive test to Digital Printable Storyboard detect recent infection is the Personal Character Letter, IgM-antibody assay. B19 IgM antibody can be detected by capture-antibody radioimmunoassay or enzyme immunoassay in approximately 90% of cases by the third day after symptoms of TAC or EI begin (57,58).

The titer and the percentage of positives begin to decline 30-60 days after onset. Template. Printable 13! B19 IgG antibody is usually present by the seventh day of illness and persists for years. B19 antibody may not be detectable in Personal Character Letter, immunodeficient patients with chronic B19 infection, and additional testing for B19 DNA or viral antigens may be necessary to document infection. B19 has not been grown in standard cell culture systems or animal model systems, but it has been grown in bone marrow explant culture systems (59). The inability to grow the virus in Chart Example, sufficient quantity to produce antigen for diagnostic assays has precluded widespread availability of Personal B19 testing (36,60,61).

Recently parvovirus B19 DNA has been incorporated into Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, the genome of a Chinese hamster ovary cell line (62). This cell line expresses B19 capsid proteins as noninfectious virionlike particles that can be used as antigen for antibody assays; this source of Personal antigen should lead to increased availability of Post You Letter. Interview diagnostic tests. Assays for B19 DNA. The most sensitive test for Letter detecting the virus is nucleic acid hybridization (63,64). This test has been used to identify B19 DNA in serum, leukocytes, respiratory secretions, urine, and tissue specimens. One group reported that B19 DNA was more likely to be detected in Analysis, leukocytes than in serum (65). Personal! Histologic Features of Story Plot Chart Example - Edgrafik B19 Infection.

Light and electron microscopy can be helpful in diagnosing B19 infections (1,23,41) By light microscopy, eosinophilic nuclear inclusions with peripheral condensation of Personal Character Letter chromatin can be seen in erythroid precursor cells of infected patients. For College |! The inclusions contain parvovirus-like particles by Character, transmission electron microscopy (28,41,66). B19-like particles may also be seen by electron microscopy in serum specimens of 20 Best Cna Appreciation Images | Nursing some infected patients (1,23,41). Histologic findings in fetal tissues also may include a severe leukoerythroblastic reaction and excessive iron deposition in tissues, which indicates hemolysis. Personal Character! Assays to Determine Site of Infection. It is not known which tissues, in addition to erythroid precursor cells, support virus replication. Several tests have been developed that distinguish virus infection of tissue or cells from Post Interview Thank Thank You Letter Interview, deposition of virus by Character Letter, passive transfer in blood. Template.! In situ hybridization can demonstrate viral DNA in Personal Character Letter, specific cells and Resume Templates For College Students |, has been used to show that B19 sometimes infects fetal myocardial cells (29). Character! Replicative forms of B19 DNA and nonstructural proteins can be demonstrated by Southern and Western blot analysis, respectively, indicating infection in the tissue (67,68).

PREVENTION OF INFECTION Risk Groups. Although B19 infection usually produces a mild, self-limited illness, three groups of persons are at Post Interview Thank Thank You Letter Interview, risk for serious complications of infection: 1) persons with chronic hemolytic anemias, 2) persons with congenital or acquired immunodeficiencies, and 3) pregnant women. Since infection in these persons can lead to substantial morbidity #12;and some mortality, consideration should be given to preventing or ameliorating disease. Immunization Active. There is no vaccine to prevent B19, but a recently developed cell line that expresses B19 capsid proteins as noninfectious viruslike particles has been proposed as a source of antigen for development of a candidate vaccine (62). Passive. No studies have been conducted to determine whether preexposure or postexposure prophylaxis with commercially available immune globulin (IG) preparations would prevent infection or modify the course of Personal Character Letter illness during community outbreaks. Routine prophylaxis with IG cannot be recommended at Analysis, this time. Health-Care Settings.

Guidelines for isolation precautions in hospitals have been published for EI (69), but recent information suggests that these guidelines should be modified. Most patients with EI are past their period of infectiousness and do not present a risk for Character Letter further transmission; thus isolation precautions are not indicated. However, there is risk for nosocomial transmission of B19 from Digital Storyboard Printable Storyboard, patients with TAC and from immunodeficient patients with chronic B19 infection. These patients should be considered infectious and Character Letter, placed on isolation precautions for Analysis 02282017 the duration of their illness or until the infection has been cleared. Nosocomial transmission of B19 has been associated with one case of TAC (70). Transmission of B19 infection has also occurred in medical research laboratories (4,71). Patients with TAC or chronic B19 infection should be admitted to private rooms. Personal Letter! Persons in close contact with the patients should wear masks. Gloves should be worn by persons likely to touch infective material such as respiratory secretions, and gowns should be worn when soiling is Interview Interview anticipated (contact isolation) (69). Hands should be washed after the patient or potentially contaminated articles are touched and before care is provided to another patient. Character! B19-infected patients may share a room with another B19-infected patient unless sharing is Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 contraindicated by another infection or condition.

Health-care workers should be advised that they are at risk of B19 infection after exposure in the hospital or in the community and that there may be a risk for further transmission to patients. Routine infection-control practices should minimize the risk of transmission. Personnel who may be pregnant or who might become pregnant should know about potential risks to the fetus from B19 infection and about preventive measures that may reduce those risks. Homes, Schools, and Workplaces. When outbreaks of B19 infection occur in situations in which prolonged, close contact exposures occur (e.g., at home, in schools, or in day-care centers), options for preventing transmission are limited. The greatest risk of Character transmitting the virus occurs before symptoms of EI develop; therefore, transmission cannot be prevented by identifying and Templates |, excluding persons with EI. The efficacy of Letter decontaminating toys and environmental surfaces to decrease B19 transmission has not been studied. | Nursing Assistant! The efficacy of handwashing to decrease B19 transmission has not been studied either, but handwashing is recommended as a practical and Personal, probably effective measure. When outbreaks occur, parents of school-aged children and Story Chart Example - Edgrafik, employees should be advised about the risk of transmitting and acquiring infection and about who is at risk for serious complications.

Persons who wish to obtain additional information about risks and management of B19 exposures should be referred to their health-care provider and state or local health officials. The decision to Personal Character Letter try to decrease any person's risk of infection by avoiding a workplace or school evironment in which an EI outbreak is occurring should be made by the person after discussions with family members, health-care providers, public health officials, and employers or school officials. A policy to routinely exclude members of high-risk groups is not recommended. PATIENT MANAGEMENT Patients with Chronic Hemolytic Anemia. The exposed patient with chronic hemolytic anemia should be managed by alerting the patient or his/her parents or guardians about the exposure, the symptoms and signs associated with TAC (pallor, weakness, and lethargy), and Interview You Letter. Thank You Letter, the need to consult a physician immediately if symptoms or signs of TAC develop.

Management of the Personal Letter, patient with TAC is based on treating symptoms of the associated anemia and For College |, may require blood transfusion. Patients with Congenital and Acquired Immunodeficiencies. The exposed patient with a congenital or acquired immunodeficiency should be managed by advising the patient or his/her parents or guardians about the exposure and the possibility that B19 infection may lead to chronic anemia. The physician should consider B19 infection in the differential diagnosis of chronic anemia in this group of patients, especially if there is an outbreak of EI in the community. #12; In several patients with acute lymphocytic leukemia, the administration of IG resulted in Character, disappearance of Interview You Letter. You Letter Post viremia and improvement in red cell indices (10). In other patients, the Personal Character, infection and associated anemia resolved when immune function returned (12,14). The role of IG in the treatment of these patients needs further study. Hpe Competitive Report! Pregnant Women. The knowledge that B19 infection during pregnancy can cause fetal death has created concern among health-care providers, public health officials, and pregnant women and their families.

In managing exposed pregnant women, risks should be considered in the context of other risks to Letter the pregnancy and the risks associated with intervention. For women with a documented infection, maternal serum #156;ga-fetoprotein levels and 20 Best Cna Appreciation Assistant, diagnostic ultrasound examinations have been used to identify adversely affected fetuses, but the sensitivity and specificity of these tests, their appropriate timing, and the risks and Personal, benefits of Post Interview Thank their use in managing infected pregnant women have not yet been determined (39,41). Interpretation of the ultrasound is difficult early in pregnancy and should be supervised by Character, a physician experienced in diagnosing fetal abnormalities. Story! Intrauterine blood transfusion (IBT) has been proposed as treatment for the fetus with B19-induced severe anemia. However, IBT is a high-risk, specialized procedure of unproven benefit in Letter, this situation and cannot be recommended for routine treatment of B19-related hydrops fetalis (72). AVAILABILITY OF DIAGNOSTIC TESTING AT CDC. Diagnostic testing is available at only a few sites, primarily research laboratories; increasing the availability of Digital Printable Templates diagnostic testing is Personal Character Letter a public health priority. The Division of Viral Diseases, Center for 20 Best Cna Appreciation Images Assistant Infectious Diseases, CDC, can accept a limited number of specimens for B19 diagnostic testing. At this time, CDC is accepting specimens through state health departments from patients with TAC, immunodeficient patients with chronic anemia, pregnant women exposed to B19 or with symptoms suggestive of B19 infection, and cases of Personal Character nonimmune fetal hydrops possibly related to B19 infection, and not accepting specimens for routine antibody testing. Physicians can arrange testing at CDC by Post Interview You Letter Post Interview, consulting their state health department.

PRIORITIES FOR FUTURE RESEARCH. The following areas have been identified as high priorities for future public health-related research on B19 infection: Develop surveillance methods that distinguish outbreaks from sporadic disease. Personal Letter! 2.Refine estimates of infection rates following exposures in You Letter. Thank Interview, the home, the Character Letter, workplace, and Resume, school. 3.Refine risk estimates for adverse fetal outcomes associated with B19 infection during pregnancy.

4.Evaluate methods to treat and Personal, prevent B19-related fetal hydrops. 5.Determine the Templates Students, disease burden associated with B19 infection in immunodeficient patients, including patients with HIV infection. 6.Determine the risk of infection and factors associated with transmission in health-care settings. 7.Determine the efficacy of IG for prevention and treatment of B19 infection. Personal! 8.Determine the potential reduction in morbidity and mortality associated with development and use of a B19 vaccine. Reported by: Div of Reproductive Health, Center for Digital Storyboard Template. Storyboard Chronic Disease Prevention and Health Promotion; Div of Immunization, Center for Prevention Svcs; Div of Birth Defects and Developmental Disabilities, Center for Environmental Health and Injury Control; Div of Character Surveillance and Epidemiologic Studies, Epidemiology Program Office; National Institute for Occupational Safety and Health; AIDS Program, Hospital Infections Program, Div of Host Factors, Div of Viral Diseases, Center for Infectious Diseases, CDC. Cossart YE, Field AM, Cant B, Widdows D. Report 02282017! Parvovirus-like particles in human sera.

Lancet 1975;1:72-3. Letter! 2.Anderson MJ, Jones SE, Fisher-Hoch SP, et al. Human parvovirus, the cause of erythema infectiosum (fifth disease)? (Letter). Resume |! Lancet 1983;1:1378. 3.Anderson MJ, Lewis E, Kidd IM, Hall SM, Cohen BJ. An outbreak of erythema infectiosum associated with human parvovirus infection. J Hyg (Lond) 1984;93:85-93. Letter! 4.Pattison JR, Jones SE, Hodgson J, et al.

Parvovirus infections and hypoplastic crisis in sickle-cell anaemia (Letter). Lancet 1981;1:664-5. 5.Knott PD, Welply GAC, Anderson MJ. Serologically proved intrauterine infection with parvovirus. Br Med J 1984;289:1660. 6.Brown T, Anand A, Ritchie LD, Clewley JP, Reid TMS. Intrauterine parvovirus infection associated with hydrops fetalis (Letter). Lancet 1984;2:1033-4.

7.White DG, Woolf AD, Mortimer PP, Cohen BJ, Blake DR, Bacon PA. Human parvovirus arthropathy. Lancet 1985;1:419-21. Post Thank Thank You Letter Post Interview! #12;8.Reid DM, Reid TMS, Brown T, Rennie JAN, Eastmond CJ. Human parvovirus-associated arthritis: a clinical and laboratory description. Lancet 1985;1:422-5. 9.Van Horn DK, Mortimer PP, Young N, Hanson GR. Human parvovirus-associated red cell aplasia in the absence of underlying hemolytic anemia. Personal Letter! Am J Pediatr Hematol Oncol 1986;8:235-9. 10.Kurtzman GJ, Ozawa K, Cohen B, Hanson G, Oseas R, Young NS. Resume For College! Chronic bone marrow failure due to persistent B19 parvovirus infection.

N Engl J Med 1987;317:287-94. 11.Davidson JE, Gibson B, Gibson A, Evans TJ. Parvovirus infection, leukaemia, and immunodeficiency (Letter). Lancet 1989;1:102. 12.Smith MA, Shah NR, Lobel JS, Cera PJ, Gary GW, Anderson LJ. Severe anemia caused by Character, human parvovirus in Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, a leukemia patient on maintenance chemotherapy. Clin Pediatr 1988:27:383-6.

13.Kurtzman GJ, Cohen B, Meyers P, Amunullah A, Young NS. Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia. Lancet 1988;2:1159-62. Character Letter! 14.Coulombel L, Morinet F, Mielot F, Tchernia G. Parvovirus infection, leukaemia, and immunodeficiency (Letter). Cna Appreciation Images Assistant! Lancet 1989;1:101-2. 15.Siegl G, Bates RC, Berns KI, et al. Characteristics and taxonomy of Parvoviridae.

Intervirology 1985;23:61-73. 16.Paver WK, Clarke SKR. Personal Letter! Comparison of human fecal and serum parvo-like viruses. J Clin Microbiol 1976;4:67-70. 17.Simpson RW, McGinty L, Simon L, Smith CA, Godzeski CW, Boyd RJ. Association of parvoviruses with rheumatoid arthritis of humans.

Science 1984;223:1425-8. 18.Anderson LJ. Role of parvovirus B19 in human disease. Pediatr Infect Dis J 1987;6:711-8. 19.Plummer FA, Hammond GW, Forward K, et al. Resume For College |! An erythema infectiosum-like illness caused by human parvovirus infection. Personal Character Letter! N Engl J Med 1985;313:74-9. 20.Chorba T, Coccia P, Holman RC, et al. The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). J Infect Dis 1986;154:383-93.

21.Ager EA, Chin TDY, Poland JD. Epidemic erythema infectiosum. N Engl J Med 1966; 275:1326-31. 22.Serjeant GR, Goldstein AR. B19 virus infection and the aplastic crisis. In: Pattison JR, ed.

Parvoviruses and human disease. Digital Template. Printable 13! Boca Raton, Florida: CRC Press, 1988:85-92. 23.Young N. Hematologic and hematopoietic consequences of B19 parvovirus infection. Semin Hematol 1988;25:159-72. 24.Anderson LJ, Hurwitz ES.

Human parvovirus B19 and pregnancy. Personal! Clin Perinatol 1988; 15:273-86. 25.Porter HJ, Khong TY, Evans MF, Chan VT-W, Fleming KA. Parvovirus as a cause of Resume Students | hydrops fetalis: detection by in situ DNA hybridisation. J Clin Pathol 1988;41:381-3. Personal Character Letter! 26.Anderson MJ, Khousam MN, Maxwell DJ, Gould SJ, Happerfield LC, Smith WJ. Human parvovirus B19 and hydrops fetalis (Letter). Lancet 1988;1:535. 27.Franciosi RA, Tattersall P. Fetal infection with human parvovirus B19.

Hum Pathol 1988; 19:489-91. 28.Caul EO, Usher MJ, Burton PA. 20 Best Images On Pinterest | Nursing! Intrauterine infection with human parvovirus B19: a ight and electron microscopy study. J Med Virol 1988;24:55-66. Personal Letter! 29.Porter HJ, Quantrill AM, Fleming KA. For College Students |! B19 parvovirus infection of myocardial cells (Letter).

Lancet 1988;1:535-6. 30.Public Health Laboratory Service Working Party on Character Letter Fifth Disease. Study of human parvovirus (B19) infection in pregnancy. Comm Dis Rep 1987;87/20:3. Chart Example - Edgrafik! 31.Edmonds L, Hatch M, Holmes L, et al.

Guidelines for reproductive studies in exposed human population. In: Bloom AD, Paul NW, eds. Guidelines for studies of human populations exposed to mutagenic and Personal Character, reproductive hazards: proceedings of conference held January 26-27, 1981, in Washington, DC. White Plains, New York: March of Dimes Birth Defects Foundation, 1981:71. 32.Kinney JS, Anderson LJ, Farrar J, et al. Risk of adverse outcomes of pregnancy after human parvovirus B19 infection.

J Infect Dis 1988;157:663-7. 33.Siegl G. Biology and pathogenicity of Resume For College autonomous parvoviruses. Personal Character! In: Berns KI, ed. The parvoviruses. Digital Storyboard Template. Printable! New York: Plenum Press, 1984:297-362. 34.Weiland HT, Vermey-Keers C, Salimans MMM, Fleuren GJ, Verwey RA, Anderson MJ.

Parvovirus B19 associated with fetal abnormality (Letter). Lancet 1987;1:682-3. 35.Rodis JF, Hovick TJ Jr, Quinn DL, Rosengren SS, Tattersall P. Human parvovirus infection in Letter, pregnancy. Obstet Gynecol 1988;72:733-8. 36.Young N, Harrison M, Moore J, Mortimer P, Humphries RK. Direct demonstration of the human parvovirus in erythroid progenitor cells infected in vitro. J Clin Invest 1984; 74:2024-32. 37.Anderson MJ, Higgins PG, Davis LR, et al. Experimental parvoviral infection in Story - Edgrafik, humans.

J Infect Dis 1985;152:257-65. 38.Potter CG, Potter AC, Hatton CSR, et al. Variation of erythroid and myeloid precursors in Personal Character Letter, the marrow and peripheral blood of volunteer subjects infected with human parvovirus (B19). J Clin Invest 1987;79:1486-92. #12;39.Carrington D, Gilmore DH, Whittle MJ, et al. Maternal serum alpha-fetoprotein--a marker of fetal aplastic crisis during intrauterine human parvovirus infection. 20 Best Cna Appreciation On Pinterest! Lancet 1987;1:433-5.

40.Schwarz TF, Roggendorf M, Deinhardt F. Letter! (Letter). Lancet 1987;1:739. 41.Anand A, Gray ES, Brown T, Clewley JP, Cohen BJ. Human parvovirus infection in pregnancy and hydrops fetalis. N Engl J Med 1987;316:183-6. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119! 42.Bond PR, Caul EO, Usher J, Cohen BJ, Clewley JP, Field AM. Intrauterine infection with human parvovirus (Letter). Lancet 1986;1:448-9. 43.Woernle CH, Anderson LJ, Tattersall P, Davison JM.

Human parvovirus B19 infection during pregnancy. J Infect Dis 1987;156:17-20. 44.Maeda H, Shimokawa H, Satoh S, Nakano H, Nunoue T. Nonimmunologic hydrops fetalis resulting from intrauterine human parvovirus B-19 infection: report of two cases. Personal Character Letter! Obstet Gynecol 1988;72:482-5. 45.Courouce AM, Ferchal F, Morinet F, et al. Human parvovirus infections in France (Letter). Lancet 1984;1:160. 20 Best Cna Appreciation On Pinterest | Nursing! 46.Okochi K, Mori R, Miyazaki M, Cohen BJ, Mortimer PP. Personal! Nakatani antigen and human parvovirus (B19) (Letter). Lancet 1984;1:160-1.

47.Goldstein AR, Anderson MJ, Serjeant GR. Parvovirus associated aplastic crisis in homozygous sickle cell disease. Arch Dis Child 1987;62:585-8. 48.Anderson MJ, Cohen BJ. Human parvovirus B19 infections in Plot Example - Edgrafik, United Kingdom 1984-86 (Letter). Lancet 1987;1:738-9.

49.Naides SJ. Erythema infectiosum (fifth disease) occurrence in Iowa. Am J Public Health 1988;78:1230-1. Character! 50.Anderson MJ, Cherry JD. Parvoviruses. Post Interview Post! In: Feigin RD, Cherry JD, eds. Textbook of pediatric infectious diseases. 2nd ed. Philadelphia: WB Saunders, 1987:1646-53. 51.Cohen BJ, Buckley MM. Character! The prevalence of antibody to Students | human parvovirus B19 in Personal Character, England and Wales.

J Med Microbiol 1988;25:151-3. 52.Mortimer PP, Cohen BJ, Buckley MM, et al. Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119! Human parvovirus and the fetus (Letter). Lancet 1985;2:1012. 53.Saarinen UA, Chorba TL, Tattersall P, et al.

Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia. Blood 1986;67:1411-7. Personal Character! 54.Mortimer PP, Luban NLC, Kelleher JF, Cohen BJ. Transmission of serum parvovirus-like virus by For College, clotting-factor concentrates. Lancet 1983;2:482-4. 55.Bartolomei Corsi O, Assi A, Morfini M, Fanci R, Rossi Ferrini P. Human parvovirus infection in haemophiliacs first infused with treated clotting factor concentrates. J Med Virol 1988;25:165-70. 56.Shneerson JM, Mortimer PP, Vandervelde EM. Letter! Febrile illness due to a parvovirus. Br Med J 1980;1:1580. On Pinterest | Nursing! 57.Cohen BJ, Mortimer PP, Pereira MS.

Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J Hyg (Lond) 1983;91:113-30. 58.Anderson LJ, Tsou C, Parker RA, et al. Detection of antibodies and Character Letter, antigens of human parvovirus B19 by Hpe Competitive Analysis 02282017, enzyme-linked immunosorbent assay. J Clin Microbiol 1986;24:522-6. 59.Ozawa K, Kurtzman G, Young N. Productive infection by B19 parvovirus of human erythroid bone marrow cells in Personal Letter, vitro. Blood 1987;70:384-91. 20 Best Images! 60.Mortimer PP, Humphries RK, Moore JG, Purcell RH, Young NS. A human parvovirus-like virus inhibits haematopoietic colony formation in vitro.

Nature 1983;302:426-9. Letter! 61.Young NS, Mortimer PP, Moore JG, Humphries RK. Characterization of a virus that causes transient aplastic crisis. J Clin Invest 1984;73:224-30. 62.Kajigaya S, Fujita S, Ozawa K, et al. A cell line that expresses B19 parvovirus structural proteins and produces empty capsids (Abstract no. 86). Blood 1988;72(suppl 1). 63.Anderson MJ, Jones SE, Minson AC. Diagnosis of human parvovirus infection by dot-blot hybridization using cloned viral DNA. Chart - Edgrafik! J Med Virol 1985;15:163-72.

64.Clewley JP. Detection of human parvovirus using a molecularly cloned probe. J Med Virol 1985;15:173-81. 65.Kurtzman GJ, Gascon P, Caras M, Cohen B, Young NS. B19 parvovirus replicates in circulating cells of acutely infected patients. Blood 1988;71:1448-54. 66.Knisely AS, O'Shea PA, McMillan P, Singer DB, Magid MS.

Electron microscopic identification of parvovirus virions in erythroid-line cells in fatal hydrops fetalis. Personal Character Letter! Pediatr Pathol 1988;8:163-70. 67.Ozawa K, Kurtzman G, Young N. Replication of the B19 parvovirus in human bone marrow cell cultures. Science 1986;233:883-6. 68.Cotmore SF, McKie VC, Anderson LJ, Astell CR, Tattersall P. Identification of the major structural and nonstructural proteins encoded by human parvovirus B19 and mapping of their genes by procaryotic expression of isolated genomic fragments. J Virol 1986; 60:548-57. 69.Garner JS, Simmons BP.

Guideline for isolation precautions in hospitals. Infect Control 1983;4(suppl):245-325. 70.Evans JPM, Rossiter MA, Kumaran TO, Marsh GW, Mortimer PP. Human parvovirus aplasia: case due to cross infection in Resume For College |, a ward. Br Med J 1984;288:681. #12;71.Cohen BJ, Courouce AM, Schwarz TF, Okochi K, Kurtzman GJ. Laboratory infection with parvovirus B19 (Letter). J Clin Pathol 1988;41:1027-8.

72.Schwarz TF, Roggendorf M, Hottentrager B, et al. Human parvovirus B19 infection in pregnancy (Letter). Lancet 1988;2:566-7. *The information and recommendations in this document were developed and compiled by CDC in consultation with representatives of the American Academy of Personal Character Letter Family Physicians, American Academy of Pediatrics, American College of Obstetricians and Gynecologists, American College of Physicians, Council of State and Territorial Epidemiologists, Immunization Practices Advisory Committee, and the National Institutes of Health. The consultants also included MJ Anderson, PhD, University College and Middlesex School of Medicine, London; SM Hall, MBBS, Communicable Disease Surveillance Centre, London; and Hpe Competitive Report, GR Serjeant, MBBS, University of West Indies, Kingston. Personal! These recommendations may not reflect the views of individual consultants or the organizations they represented.

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Essay: Evolution and Charles Darwin. I. Evolution is the most important concept in all of biology. None of biology makes sense except in the context of evolution. Just why is evolution so important to biologists? A few examples’ A. Taxonomy: Evolution makes sense of the similarities and Character Letter, differences and provides a rational explanation for the distribution of taxa. It also supplies explanations for the sometimes wild exceptions we see (eg cacti and euphorbs, which look so similar but are clearly only very distantly related to each other. The explanation is convergent evolution). B. Molecular biology: Comparison of DNA and Chart, protein sequences only Letter, makes sense in light of evolution. C. Medicine: Our understanding of infectious organisms and our tactics to combat them are entirely based upon understanding of evolution. II.

No idea comes from thin air. The historical perspective helps to understand where the Resume Templates Students | concepts behind evolutionary theory came from. Here are some of the basic historical issues. A. The typical view of the Letter nature of species at the beginning of the nineteenth century is Templates For College, often described as the Doctrine of Character Fixed Species. Digital Storyboard Printable Templates. This concept had its primary roots in Greek philosophy: Aristotle’s Scala Naturae (The ‘Great Chain of Being’) and Plato’s essentialism. B. During the Character eighteenth century, Carolus Linnaeus (1707-1778) developed the basis for our nested, hierarchical classification system, or Taxonomy. This system is also a ‘natural’ system, meaning that, regardless of the For College | characters of organisms chosen as the basis for the classification, species almost always end up classified in the same pattern, an oddity which didn’t escape early 19th century naturalists, and which led to all kinds of evolutionary thinking. C. The geologic discipline of stratigraphy was developed during the late eighteenth and early nineteenth centuries. Though this accomplishment was shared by many geologists throughout Europe, the name most commonly associated with developing the concept of stratigraphy is William Smith (1769-1839), who was an engineer engaged in Letter building canals all over England. D. George Cuvier (eventually Baron George Cuvier) (1769-1832) was a scientist of the late 18th and early 19th centuries. His specialty was vertebrate anatomy.

He developed the important technique of comparative anatomy, which is based upon the understanding that the parts of an animal aren’t just unrelated bits stuck together’they reflect the Report life style and Personal Character, type of the animal, and are thus all related to each other. On Pinterest Assistant. Because of his expertise in anatomy, Cuvier was the obvious person to ask to Personal Letter examine strange remains found during reconstruction after a major Paris fire. These remains turned out to belong to extinct organisms, and led to the development of the Post Interview field of Letter study we call Paleontology. Cuvier was the first to reconstruct dinosaurs. Cuvier is also remembered for coming up with the concept of Catastrophism, as an attempt to reconcile his religious beliefs with the evidence he discovered as a scientist. E. Charles Lyell (1797-1875), a British geologist, developed the concept of Uniformitarianism. Analysis Report 02282017. This theory of geology is often summarized by the catch phrase, ‘The present is the key to the past.’ The meaning of this phrase is that, if you can understand how geological features are being shaped and Personal, formed today, you can look at the formations from a long time ago and assume that they were created in Chart Example the same way. In other words, the forces acting upon and shaping the Earth today are the Character same as the forces that acted upon Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, and shaped the Earth in the past.

Uniformitarianism is a central tenet of modern geology. III. Charles Darwin (1809-1882) and the Origin of Letter Species. A. Who was Charles Darwin? 1. Darwin was born in the first century of the nineteenth century to a wealthy family.

He began an education in medicine (the ‘family trade’) but actually completed his degree in - Edgrafik theology. His hobby was natural history. He collected beetles, went on geological field trips and became very friendly with the natural history faculty at his universities. 2. After completing his degree, Darwin went along on a mapping expedition to South America, on a ship called the USS Beagle. Personal. During the five-year trip, he collected tons (literally) of specimens of animals, plants and fossils, which he shipped back to England for later analysis.

3. Upon returning to England, he officially became a naturalist. Almost all of his specimens were sent to experts for analysis. 20 Best Cna Appreciation On Pinterest | Nursing. He kept the barnacles for himself, setting out to Character become an expert in barnacles. It was the analyses that were returned to Printable Storyboard him from his experts that started him thinking along revolutionary pathways. 4. He began writing in journals which he called his ‘transformation notebooks.’ This is where he worked out the Character specifics of his theory (which he called ‘descent with modification. Interview Thank You Letter. Post Interview. He never liked the Personal Character Letter name ‘evolution’ for his theory, because this term was already used for the development of an embryo from a fertilized egg, a process strictly controlled and predictable, which Darwin’s theory says is not true for the history of life’s diversity. 5. Darwin read Thomas Malthus’s Essay on Populations.

Malthus (1766-1834) was an economist who wrote that people always tend to over-reproduce, but that the resources they depend upon don’t reproduce fast enough to For College continue to provide for the extended population. Thus, he said, if it weren’t for things that control population size (like war, plague, and other pleasant things), there would never be enough resources to go around. Thus, in order for humans to continue to survive, some have to die. 6. Darwin’s theory was completely developed by 1840, though he didn’t publish it until 1858, for several reasons. 7. One reason he finally published in 1858 (and then published Origin of Species in 1859) was that he discovered that another man, Alfred Russell Wallace (1823-1913), had independently discovered and Character, was about to publish exactly the same theory Darwin had been working on for 20 years. B. What exactly is the theory of evolution? Darwin’s theory has two novel concepts. 1. Darwin saw a clear pattern of common descent among the Digital Storyboard Printable Templates 13 species of Personal Character life. Digital Template. Storyboard Templates 13. Examining the expert analyses of all of the specimens from the Beagle expedition, it was clear to Darwin that the various forms of life were all descended from one, or many from a very few, common ancestral species.

Additional evidence since Darwin’s time provides very powerful support for the idea of a single ancestral species for all life on Earth. 2. The mechanism Darwin figured out by which species could change from one thing into something different was natural selection. He’d spent virtually all of his life in the country, and was very aware of how radically artificial selection by Character Letter plant and Assistant, animal breeders could alter organisms. He saw environmental competition as providing the selective pressure in nature. Natural selection was partially derived from Malthus’s ideas.

Here’s the reasoning: a. Observation: All living things tend to over-reproduce. b. Observation: Resources are finite. c. Character. Conclusion: There will be competition over resources, and Hpe Competitive Analysis Report, not all members of Character Letter any generation can survive. d. Observation: There is variation in Hpe Competitive Report 02282017 all species’a more profound statement than you might think. e. Observation: Variations in species can influence who can and who can’t get enough resources to Personal Letter survive and reproduce.

f. Observation: Many aspects of variation are heritable, meaning that they are passed from parents to offspring. g. Conclusion: Each new generation will tend to Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 be more like the successful parents and less like the unsuccessful parents. Given enough time (meaning enough generations), these changes can produce brand new species, especially if the environmental pressure is strong. IV. What is the evidence in support of the theory of Letter evolution? This question could take weeks to answer. Observations of Analysis a wide variety of phenomena demonstrate evolutionary action and consequences. Here are some examples: A. Artificial selection among plants and animals, as described above. B. Adaptive radiation, which Darwin saw abundantly demonstrated among the species he observed and collected while on Personal Character Letter the Beagle.

Adaptive radiation is the phenomenon in which a single species splinters into many daughter species. This phenomenon is very commonly observed among species living on off-shore islands like the Post Interview Thank Thank Post Galapagos Islands to the west of South America. C. The fossil record abundantly demonstrates evolutionary change. Transitional sequences show, for instance, the emergence of mammals from reptiles in the Permian Period, and Personal Character Letter, the emergence of Cetaceans from terrestrial mammals in the early Cenozoic Era. D. Biogeography (the distribution of Plot Chart Example - Edgrafik species geographically) abundantly supports evolution, specifically island biogeography, which shows us that the Letter resident species of islands are always derived from the Story Plot species on Personal Character Letter the adjacent mainland. E. Signatures of History are abundant in virtually all species.

These are physical or behavioral features which clearly show that the modern species is descended from a species that lived a different kind of life cycle. F. Molecular sequencing is an area of evidence that Darwin could never have predicted. Our modern biotechnology allows us to compare DNA and protein sequences among living organisms. Hpe Competitive Analysis Report. These comparisons clearly show the degree of relationship among different species’greater distance equates to greater molecular differences. Molecular sequencing has provided a superb method of directly testing the Personal predictions of evolutionary theory. V. What is the modern status of Darwin’s theory of evolution? A. All of the basic concepts have remained sound, and have survived extensive challenge and testing. There was a great deal of evidence in support of Resume For College | Darwin’s theory when he published it, and it has gained in acceptability and supportive evidence for nearly 150 years.

B. Do we agree with Darwin’s original theory on all points? Of course not. 150 years of gathering and examining evidence has led to some greater understandings than were possible in Darwin’s time. 1. One of the areas in which our available information is much greater is in the fossil record. We have many times more fossil evidence than Darwin did, and Personal, some things have become more clear with the greater abundance of physical evidence of extinct species. This greater knowledge has called one of Darwin’s suggestions into question.

Darwin felt that, to a large extent, new species arose from Post Interview Thank You Letter. Thank Post old species by the gradual accumulation of tiny changes, a pattern of change that has come to be called ‘Darwinian gradualism.’ If this were the Personal Character typical pattern of Digital Storyboard Templates 13 new species production, we would predict that the fossil record would contain a very high percentage of transitional forms. Personal Character. In reality, though there are many transitional fossils, they don’t occur in nearly the abundance predicted by 20 Best Images On Pinterest | Nursing gradualism. Niles Eldredge and Stephen Jay Gould proposed an alternative view, which has come to be called ‘punctuated equilibrium.’ They suggest that most species remain in stasis for long periods of time, and that when new species arise, they do so relatively rapidly (geologically speaking). 2. One of Darwin’s major problems was that, though his theory required that characteristics be passed from generation to Character generation, no one knew how that happened. There was no science of genetics in Darwin’s day’genetics is a twentieth century science. Resume Templates | Darwin suggested a method of heredity which involved the production of what he called ‘gemules’ by various parts of the body, but it was incorrect. Personal Character Letter. So this was an aspect of evolution that he could never explain satisfactorily. Plot Chart Example - Edgrafik. In the year 1900, the science of genetics was ‘born.’ Initially, Darwinists and Mendelists (geneticists, named after Gregor Mendel, who discovered the concepts of genetics) were opposed to each other.

Darwinists said that traits were inherited from generation to generation, but those traits had to Personal Letter be able to change (otherwise no evolutionary change could happen). Mendelists said genetic traits didn’t change, they just got rearranged and recombined. Growing understanding of mutation, which does change genes, allowed the two battling factions of biologists to come to an agreement. This modern version of evolution, including a mature understanding of genetics, is called Neodarwinism, or The New Synthesis. It is our modern theory of evolution’Darwin, only better. VI. Some have greatly misused Darwin’s ideas, particularly the concept of Analysis 02282017 natural selection, to support their own notions of how humans should interact with each other. The theory of evolution is a theory about how the diversity of living things has come to be; it has nothing to do with human social systems, and should never be applied in Personal Character Letter these ways. A. Social Darwinism is not actually ‘Darwinism’ of any kind. Charles Darwin himself was not a social Darwinist. It is from social Darwinists that we get the phrase, ‘survival of the fittest.’ This is an oversimplified expression of natural selection, or at least of natural selection as the social Darwinists saw it.

Social Darwinists thought that they could apply this concept to human social interactions. Thus, in human interactions, the guy who could win was clearly innately superior. Digital Template. Storyboard 13. In war, the victory would go to the superior nationality. In business, the Personal Character guy who could come out on Storyboard Template. Printable 13 top, no matter the strategies used, was obviously superior to the one who ended up on the bottom. Evolutionary theory has nothing to do with this sort of Letter thing; this is just human politics and human philosophy at work, and trying to give itself legitimacy by dressing up in the trappings of science. B. Eugenics was a specific expression of early twentieth century social Darwinism. The word literally translates as ‘good origins.’ The eugenics movement was based upon the idea that, as scientists finally understood both genetics and evolution, they could take control of the Story Plot Chart - Edgrafik evolutionary future of the Personal Character human species. Post Interview Thank. Unfortunately, actual understanding of the Character Letter complexities and realities of Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 genetics and evolution was not really available. It still isn’t available today. Letter. The primary concern of most eugenicists was the ‘problem’ of Analysis Report ‘feeblemindedness,’ which was felt to be at Personal, the root of all kinds of social ills.

Terms like ‘feebleminded,’ ‘moron,’ and ‘idiot’ were not originally used as insults. They were technical terms given to Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119 particular ranges on the I.Q. ‘bell curve.’ The feebleminded were those in the segment one standard deviation below 100’those who were of ‘substandard’ I.Q., but who could function in the world’hold down jobs, marry, have children. Character Letter. The supposition was that these folks would have way too many kids’a lot more than folks at the other end of the I.Q. scale, and would thus drag the whole human species down with their ‘stupid’ genes. So the Analysis Report 02282017 eugenicists advocated doing something about limiting the Personal Character reproduction going on in this segment of the population. In the U.S. the preferred approach was sterilization. In Nazi Germ. Search our thousands of essays:

If this essay isn't quite what you're looking for, why not order your own custom Science essay, dissertation or piece of coursework that answers your exact question? There are UK writers just like me on hand, waiting to help you. Cna Appreciation Images | Nursing Assistant. Each of us is qualified to a high level in our area of expertise, and we can write you a fully researched, fully referenced complete original answer to your essay question. Just complete our simple order form and you could have your customised Science work in your email box, in as little as 3 hours. This Science essay was submitted to us by a student in order to help you with your studies. This page has approximately words. If you use part of this page in your own work, you need to provide a citation, as follows: Essay UK, Essay: Evolution and Charles Darwin . Character Letter. Available from: [02-10-17]. If you are the original author of this content and Music-Contract-Band-Members-Agreement-1-638.jpg?cb=1376552119, no longer wish to have it published on our website then please click on the link below to request removal:

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